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Endosomal lncRNA Rmrp is required for TLR3 innate sensing by engaging TLR3 dimerization

ABSTRACT: In this study, we sequenced RNAs localized in the early endosome and lysosome and TLR3-binding RNAs, and identified Rmrp as a TLR3 binding early endosomal lncRNA. Further we investigated the biological funtion of Rmrp in vitro and in vivo, proving that Rmrp posivitely regulated TLR3 activation by inducing TLR3 dimerization. Cryo-EM structure of Rmrp-C-mTLR3-ECD complex further proved our conclusion.

ORGANISM(S): Mus musculus

PROVIDER: GSE159459 | GEO | 2025/04/01

REPOSITORIES: GEO

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