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Dnm2 downregulation by antisense oligonucleotide (ASO1) injections rescue a murine model of autosomal dominant centronuclear myopathy (Dnm2SL/+)

ABSTRACT: In this study, we performed RNA sequencing on tibialis anterior muscle of male mice. WT (injected with ASO control) and Dnm2SL/+ (injected with ASO control) mice as well as ASO1 injected Dnm2SL/+ mice and ASO1 injected WT mice were sequenced at 7w of age. ASO1 targets specifically Dnm2 ARN.

ORGANISM(S): Mus musculus

PROVIDER: GSE160078 | GEO | 2020/12/15

REPOSITORIES: GEO

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Dnm2 downregulation by antisense oligonucleotide (ASO1) injections rescue a murine model of recessive centronuclear myopathy (Bin1mck-/-)

Project description:In this study, we performed RNA sequencing on tibialis anterior muscle of male mice. WT (injected with PBS) and Bin1mck-/- (injected with PBS) mice as well as ASO1 injected Bin1mck-/- mice and ASO1 injected WT mice were sequenced at 7 weeks of age. ASO1 targets specifically Dnm2 ARN.

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Project description:Dnm2 downregulation by antisense oligonucleotide (ASO1) injections rescue a murine model of autosomal dominant centronuclear myopathy (Dnm2SL/+)

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Dnm2 downregulation by antisense oligonucleotide (ASO1) injections rescue a murine model of recessive centronuclear myopathy (Bin1mck-/-)

Project description:Dnm2 downregulation by antisense oligonucleotide (ASO1) injections rescue a murine model of recessive centronuclear myopathy (Bin1mck-/-)

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