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ZIKV prevents host mRNA export from the nucleus by disrupting UPF1 function

ABSTRACT: Zika virus (ZIKV) is a mosquito-borne virus that can have dramatic neurodevelopmental consequences when infection occurs in utero. Previous studies demonstrated that ZIKV downregulates the master regulator of nonsense mediated decay, UPF1. To examine whether this process contributes to disruption of neural development, we investigated the effect of ZIKV infection on UPF1 interaction with host RNA in neural progenitor cells. Here, we show that ZIKV-mediated disruption of UPF1 function in neural progenitor cells causes retention of mRNA in the nucleus, resulting in decreased protein levels of specific transcripts involved in neural differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE160201 | GEO | 2022/12/22

REPOSITORIES: GEO

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ZIKV prevents host mRNA export from the nucleus by disrupting UPF1 function

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