Transcriptomics

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Global gene profiling comparison between hydrogen sulfide- and N-methyl-D-aspartate-induced neuronal deaths


ABSTRACT: Hydrogen sulfide (H2S), present in abundance in the mammalian brain, has recently been demonstrated to induce a dose- and time-dependent apoptotic-necrotic continuum in murine primary cortical neurons, which was successfully attenuated upon application of N-methyl-D-aspartate (NMDA) receptor antagonist. The current study focused on gaining an insight into the molecular mechanisms of H2S–mediated neuronal death pertaining to NMDA receptors activation through global gene expression comparisons.

ORGANISM(S): Mus musculus

PROVIDER: GSE16035 | GEO | 2013/01/23

SECONDARY ACCESSION(S): PRJNA115395

REPOSITORIES: GEO

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