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Tumor-suppressive and tumor-promoting roles of cancer-associated fibroblast-released mediators in desmoplastic liver metastasis

ABSTRACT: Here we analyzed mouse derived samples to investigate origin, subtypes, functions and cell-cell interactions of cancer-associated fibroblasts in desmoplastic liver metastasis. Hepatic stellate cell-derived cancer-associated fibroblasts were isolated from three different models of liver metastasis induced by intra-splenic injection of cell lines Panc02, KPCY and CMT93 and analyzed by bulk RNA sequencing. In addition, CAF from Panc02- and CMT93-induced liver metastasis were analyzed by single cell sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE160541 | GEO | 2021/11/01

REPOSITORIES: GEO

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