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Expression data from mouse liver after chow and high-fat diet feeding

ABSTRACT: Epigenetic changes are present in multiple tissues of rodents and subjects suffering from obesity and type 2 diabetes. Especially, genes that are important for glucose and lipid metabolism seem to be at least co-regulated by DNA methylation. We aimed to investigate if altered DNA methylation in liver of mice can be induced by feeding a high-fat diet and if these changes can be reverted by weight loss. We used microarrays to measure the hepatic gene expression pattern in chow and high-fat diet (HFD) fed mice to identify dysregulated pathways which contribute to diet-induced obesity and insulin resistance. DNA methylation was measured of candidate genes to evaluate this as potential regulatory mechanism.

ORGANISM(S): Mus musculus

PROVIDER: GSE160646 | GEO | 2021/01/31

REPOSITORIES: GEO

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