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Analysis on Replication and Transcription of SARS-CoV-2 and inhition effect of Remdesivir

ABSTRACT: SARS-CoV-2, a betacoronavirus with a positive-sense, single-stranded RNA genome, caused the COVID-19 pandemic with unprecedent health and socio-economic crisis. Although its general sense mRNA architecture was reported, that of its negative strand was unexplored. We combined poly(A)-mRNA and ribosomal RNA-depleted sequencing to delineate several fine features of both RNA strands. Together with the transcriptome data under the perturbation of anti-viral drug Remdesivir, this project opens new sights into SARS-CoV-2 replication mechanism and may facilitate the anti-viral drug design.

ORGANISM(S): Chlorocebus sabaeus Severe acute respiratory syndrome coronavirus 2

PROVIDER: GSE160668 | GEO | 2021/06/27

REPOSITORIES: GEO

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