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Genome-wide Profiling of RNA Binding Targets of hnRNP H

ABSTRACT: To inform the mechanism of hnRNP H dysfunction in methamphetamine-induced dopamine release and behavior, we surveyed mRNA targets of hnRNP H via cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-seq) in striatal tissue at baseline and at 30 min post-MA (2 mg/kg, i.p.). To integrate identification of hnRNP H targets with the impact of Hnrnph1 mutation and methampetamine on downstream gene expression and splicing, we analyzed the transcriptome of the parallel samples used in CLIP-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE160682 | GEO | 2020/11/03

REPOSITORIES: GEO

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