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Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium [single cell RNA-seq]

ABSTRACT: We profile the transcriptomes of over 5,000 mouse single cells, yielding molecular definitions for mesenchymal cell types present in heathy cycling mouse uterus. We uncover novel heterogeneity within the Pdgfrb+ mesenchymal cell compartment of the mouse uterus, defining five subpopulations including two closely related Cspg4+ pericytes/vascular smooth muscle cells and three Pdgfra+Cd34+ subpopulations of fibroblasts.Our work dissects cellular heterogeneity within the mouse uterine mesenchyme providing a platform to understand the roles of these cell populations in uterine physiology and disease and for comparisons between mesenchymal cells in endometirum and other adult tissue which are prone to fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE160772 | GEO | 2020/11/16

REPOSITORIES: GEO

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Single cell RNA sequencing redefines the mesenchymal cell landscape of mouse endometrium [bulkRNAseq]

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Gene expression profiling of uterine epithelial cells isolated from Msx1Msx2 floxed and Msx1Msx2 ablated mice on day 4 of pregnancy

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