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Therapeutic PYY/GLP-1 receptor co-agonism in obese-diabetic mice

ABSTRACT: Therapeutic PYY/GLP-1 receptor co-agonism in obese-diabetic mice synergistically activates discrete hypothalamic and brainstem neuronal circuitries for weight reduction, increased insulin sensitization, recovery of pancreatic ß-cell function and diabetes remission. GLP1-R agonism (IP118) and PYY-2R agonism (PY115) in combination yield surprising synergistic effects on energy homeostasis in mammals. To better understand the genesis of these effects, RNAseq profiling was performed on key brain regions following an acute dose of IP118+PY115.

ORGANISM(S): Mus musculus

PROVIDER: GSE160802 | GEO | 2021/03/01

REPOSITORIES: GEO

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