Transcriptomics

Dataset Information

0

Heterocellular OSM-OSMR signalling drives pancreatic cancer growth and metastasis through functional fibroblast reprogramming


ABSTRACT: Pancreatic ductal adenocarcinoma (PDA) is a lethal malignancy characterised by a pathological fibroinflammatory microenvironment. Dichotomous tumour-promoting and -restrictive roles have been ascribed to the tumour microenvironment, however the effects of individual stromal subsets remains incompletely characterised. Here, we describe how heterocellular OSM-OSMR signalling instructs fibroblast reprogramming, tumour growth and metastasis. Macrophage-secreted OSM stimulates inflammatory gene expression in cancer-associated fibroblasts (CAFs), which in turn induce a pro-tumorigenic environment and engage tumour cell survival and migratory signalling pathways. Tumour cells implanted in Osm-deficient (Osm-/-) mice display an epithelial-dominated morphology, reduced tumour growth and did not metastasise. Moreover, the tumour microenvironment of Osm-/- animals exhibit increased abundance of αSMApos myofibroblasts and a shift in myeloid and T cell phenotypes, consistent with a more immunogenic environment. Taken together, these data demonstrate how OSM-OSMR signalling coordinates heterocellular interactions to drive a pro-tumorigenic environment in PDA.

ORGANISM(S): Mus musculus

PROVIDER: GSE161359 | GEO | 2021/08/30

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-11-29 | PXD022484 | Pride
2015-06-27 | E-GEOD-70351 | biostudies-arrayexpress
| PRJNA677956 | ENA
2019-09-30 | GSE135434 | GEO
2019-09-30 | GSE135433 | GEO
2011-09-29 | E-GEOD-27480 | biostudies-arrayexpress
2015-06-27 | GSE70351 | GEO
2011-09-30 | GSE27480 | GEO
2011-02-16 | E-GEOD-27332 | biostudies-arrayexpress
2011-02-16 | E-GEOD-27331 | biostudies-arrayexpress