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MiRNA content from human and mouse epicardial extracellular vesicles

ABSTRACT: The goal of the present study is to determine the miRNA cargo present in epicardial extracellular vesicles. For that, epicardial cells and human primary epicardial cells were cultured. Conditioned media was isolated from mouse epicardial cells and human primary epicardial cells derived from right atrial appendages in two different states: “cobble” (inactive) cells and “spindle” (active) . RNA from EVs was isolated and sequenced to determine the miRNA content profile.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE161630 | GEO | 2020/11/18

REPOSITORIES: GEO

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miRNA content from human and mouse epicardial extracellular vesicles

Project description:miRNA content from human and mouse epicardial extracellular vesicles

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Project description:The overall goal of this study is to determine the transcriptomic consequences of the absence of epicardial-derived cells in the parietal leaflets of the atrioventricular valves as a consequence of epicardial deletion of Sox9.

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