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Self-renewing Endometrial Epithelial Organoids of the Human Uterus [single-cell RNA-seq data]

ABSTRACT: The inner lining of the human uterus, termed the endometrium, is replete with glands that are hypothesized to be important for establishment of pregnancy through interactions with other endometrial cells and the embryo. A three-dimensional culture system was utilized to establish and generate endometrial epithelial organoids from normal human endometrium that display long-term expandability, can be cryopreserved, and are hormone responsive. Here, single cell RNA-seq was used to create a high-resolution gene expression atlas of the endometrial epithelial organoids and to define responsiveness to reproductive hormones.

ORGANISM(S): Homo sapiens

PROVIDER: GSE161937 | GEO | 2020/11/22

REPOSITORIES: GEO

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