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Effect of MOG-7 disruption on the C. elegans transcriptome

ABSTRACT: In higher eukaryotes, splicing of introns from pre-mRNAs is required for gene expression. Here, we report that Caenorhabditis elegans MOG-7 is a hybrid RNA splicing factor that contains conserved splicing domains from both yeast and mammals. Acute removal of MOG-7 from the C. elegans germline causes intron retention in the majority of genes, resulting in sterility, germline masculinization and germ cell morphology defects. Despite the deleterious consequences caused by MOG-7 loss, the germline can functionally recover to produce viable and fertile progeny once MOG-7 expression is restored through apoptotic clearance of defective germ cells.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE162055 | GEO | 2022/04/13

REPOSITORIES: GEO

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