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Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ANRIL_DEx8_Affy]

ABSTRACT: To identify the genes differentially expressed upon removal of the Exon8 of the lncRNA ANRIL in HEK293 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE162222 | GEO | 2021/05/26

REPOSITORIES: GEO

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Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ChIRP-seq]

Project description:We performed Chromatin Isolation by RNA Purification (ChIRP-seq) of the lncRNA ANRIL in HEK293 cell line. We identified 3227 genomic regions to be contacted by ANRIL.

2021-05-26 | GSE162221 | GEO

Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL [ANRIL_LNA_Affy]

Project description:To identify the genes differentially expressed upon the knockdown of the lncRNA ANRIL using LNA GapmeRs in HEK293 cells

2021-05-26 | GSE162223 | GEO

Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL.

Project description:Long non-coding RNAs have emerged as critical regulators of cell homeostasis by modulating gene expression at chromatin level for instance. Here, we report that the lncRNA ANRIL, associated with several pathologies, binds to thousands of loci dispersed throughout the mammalian genome sharing a 21-bp motif enriched in G/A residues. By combining ANRIL genomic occupancy with transcriptomic analysis, we established a list of 65 and 123 genes potentially directly activated and silenced by ANRIL in trans, respectively. We also found that Exon8 of ANRIL, mainly made of transposable elements, contributes to ANRIL genomic association and consequently to its trans-activity. Furthermore, we showed that Exon8 favors ANRIL's association with the FIRRE, TPD52L1 and IGFBP3 loci to modulate their expression through H3K27me3 deposition. We also investigated the mechanisms engaged by Exon8 to favor ANRIL's association with the genome. Our data refine ANRIL's trans-activity and highlight the functional importance of TEs on ANRIL's activity.

| S-EPMC8136789 | biostudies-literature

Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-05-26 | GSE162224 | GEO

Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL

Project description:Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL

| PRJNA681140 | ENA

Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ANRIL_DEx8_Affy]

Project description:Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ANRIL_DEx8_Affy]

| PRJNA681144 | ENA

Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL [ANRIL_LNA_Affy]

Project description:Implication of repeat insertion domains in the trans-activity of the long non-coding RNA ANRIL [ANRIL_LNA_Affy]

| PRJNA681145 | ENA

Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ChIRP-seq]

Project description:Implication of Repeat Insertion Domains in the Trans-Activity of the Long non-coding RNA ANRIL [ChIRP-seq]

| PRJNA681143 | ENA

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

Project description:Circular RNAs (circRNAs) are broadly expressed in eukaryotic cells, but their role in human health and disease remains obscure. Here, we show that circular antisense non-coding RNA in the INK4 locus (circANRIL), which is transcribed at a locus of atherosclerotic cardiovascular disease on chromosome 9p21, confers athero-protection by controlling ribosomal RNA (rRNA) maturation and modulating pathways of atherogenesis. At the molecular level, circANRIL competes with precursor rRNA (pre-rRNA) for binding to pescadillo homolog 1 (PES1), an essential 60S-preribosomal assembly factor, thereby impairing exonuclease-mediated pre-rRNA processing and ribosome biogenesis. As a consequence, circANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key athero-protective cell functions within the arterial wall. Collectively, these findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring athero-protection, thereby unveiling a therapeutic potential of certain circRNAs in human disease. Analysis of transcriptome-wide expression level in HEK293 cells with stable overexpression of circular ANRIL (n=3) compared to a vector control (n=3).

2016-08-22 | E-GEOD-65392 | biostudies-arrayexpress

ANRIL siRNA Microarray Data in HUVECs

Project description:Coronary artery disease (CAD) is the most common cardiovascular disease and the leading cause of death worldwide. To date, the 9p21.3 locus is the most robust and frequently replicated risk locus of CAD among >90 CAD risk loci identified by GWAS. More than 50 CAD-associated genomic variants were identified at the 9p21.3 CAD locus and many of them are located within a long non-coding gene ANRIL, which was initially referred to as Antisense Non-coding RNA in INK4 Locus. The causal role of ANRIL in CAD and the underlying molecular mechanism are unknown. We used gene expression microarray to identify the downstream target genes of ANRIL and to explore molecular mechanisms by which ANRIL might contribute to the risk development of CAD.

2019-01-16 | GSE117676 | GEO

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