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Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity

ABSTRACT: Disease relapse remains common following treatment of acute myeloid leukemia (AML) and is due to chemoresistance of leukemia cells with disease repopulating potential. To date, attempts to define the characteristics of in vivo resistant blasts have focused on comparisons between leukemic cells at presentation and relapse. However, further treatment responses are often seen following relapse, suggesting that most blasts remain chemosensitive. Here we characterize in vivo chemoresistant blasts by studying the transcriptional and genetic features of blasts from before and after induction chemotherapy using paired samples from 6 patients with primary refractory AML.

ORGANISM(S): Homo sapiens

PROVIDER: GSE162542 | GEO | 2021/10/04

REPOSITORIES: GEO

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