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Role of Top1 and Genome structure in SARS-CoV-2 infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mesocricetus auratus Homo sapiens

PROVIDER: GSE162619 | GEO | 2021/03/30

REPOSITORIES: GEO

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Role of Top1 and Genome structure in SARS-CoV-2 infection [RNA-Seq hamster]

Project description:The ongoing pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is currently affecting millions of lives worldwide. Large retrospective studies indicate that an elevated level of inflammatory cytokines and pro-inflammatory factors are associated with both increased disease severity and mortality. Targeting these pathways might therefore be a viable therapeutic strategy. Previously, we have reported that chromatin factors such as Topoisomerase I (Top1) play key roles in controlling the induction of inflammatory gene expression programs. Here, by using multidimensional epigenetic, transcriptional, in vitro and in vivo analyses, we show that Topoisomerase 1 (Top1) inhibition in infected cells and animals suppresses lethal inflammation induced by SARS-CoV-2.

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