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Using ATAC-Seq to investigate the impact of vaccination on the epigenome

ABSTRACT: We used a mouse model to investigate whether live (BCG) and non-live (DTPw) vaccines differentially reprogram trained immune responses and to investigate whether immunisation with DTPw altered susceptibility to sepsis. We found that compared to BCG-immunised mice, DTPw immunisation led to altered monocyte and dendritic cell (DC) cytokine responses to subsequent secondary stimuli, as well as genome-wide changes to chromatin accessibility in DCs. These effects were evident months after immunisation and are consistent with different programs of trained immunity being induced by live versus non-live vaccines.

ORGANISM(S): Mus musculus

PROVIDER: GSE162872 | GEO | 2021/07/20

REPOSITORIES: GEO

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