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The role of NRF2 in the effects of methionine restriction on the transcriptome of mouse livers

ABSTRACT: Dietary methionine restriction results in a robust activation of transcription factor, NRF2, and its target gene expression in the liver. In the current study, we observed liver-specific knockout NRF2 did not affect the physiological responses due to MR consumption. Therefore, there are other transcription factors compensate for the loss of NRF2 in the liver to mediate the effect of MR. The RNAseq experiment was comducted to compare the effect of MR diet in NRF2 WT and KO mice on hepatic transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE162964 | GEO | 2021/06/30

REPOSITORIES: GEO

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Effects of 20 months Dietary Methionine Restriction on Hepatic Gene Expression in Fischer 344 Rats

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