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Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE163268 | GEO | 2023/10/25

REPOSITORIES: GEO

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Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (5hmC)

Project description:Female mouse was infected by zika virus, then subject to 5hmC capture and RNAseq, by comparing PBS treated mouse and zika infected mouse, we identified zika affected gene that regulated by 5hmC change

2023-10-25 | GSE163265 | GEO

Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (RNA-Seq)

2023-10-25 | GSE163266 | GEO

Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice

Project description:Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice

| PRJNA685446 | ENA

Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (5hmC)

Project description:Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (5hmC)

| PRJNA685598 | ENA

Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (RNA-Seq)

Project description:Maternal Zika virus infection alters epigenetic DNA modifications and leads to transgenerational behavioral changes in offspring mice (RNA-Seq)

| PRJNA685597 | ENA

Epigenetic abnormality due to maternal Zika virus infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-30 | GSE164783 | GEO

Zika virus infection of the placenta alters extracellular matrix proteome.

Project description:Zika virus (ZIKV) infection has been associated with fetal abnormalities by compromising placental integrity, but the mechanisms by which this occurs are unknown. Flavivirus can deregulate the host proteome, especially extracellular matrix (ECM) proteins. We hypothesize that a deregulation of specific ECM proteins by ZIKV, affects placental integrity. Using twelve different placental samples collected during the 2016 ZIKV Puerto Rico epidemic, we compared the proteome of five ZIKV infected samples with four uninfected controls followed by validation of most significant proteins by immunohistochemistry. Quantitative proteomics was performed using tandem mass tag TMT10plex™ Isobaric Label Reagent Set followed by Q Exactive™ Hybrid Quadrupole Orbitrap Mass Spectrometry. Identification of proteins was performed using Proteome Discoverer 2.1. Proteins were compared based on the fold change and p value using Limma software. Significant proteins pathways were analyzed using Ingenuity Pathway (IPA). TMT analysis showed that ZIKV infected placentas had 94 reviewed differentially abundant proteins, 32 more abundant, and 62 less abundant. IPA analysis results indicate that 45 of the deregulated proteins are cellular components of the ECM and 16 play a role in its structure and organization. Among the most significant proteins in ZIKV positive placenta were fibronectin, bone marrow proteoglycan, and fibrinogen. Of these, fibrinogen was further validated by immunohistochemistry in 12 additional placenta samples and found significantly increased in ZIKV infected placentas. The upregulation of this protein in the placental tissue suggests that ZIKV infection is promoting the coagulation of placental tissue and restructuration of ECM potentially affecting the integrity of the tissue and facilitating dissemination of the virus from mother to the fetus.

| S-EPMC8760362 | biostudies-literature

Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring.

Project description:BACKGROUND:Maternal infection during pregnancy is associated with an increased risk of schizophrenia and autism in the offspring. Supporting this correlation, experimentally activating the maternal immune system during pregnancy in rodents produces offspring with abnormal brain and behavioral development. We have developed a nonhuman primate model to bridge the gap between clinical populations and rodent models of maternal immune activation (MIA). METHODS:A modified form of the viral mimic, synthetic double-stranded RNA (polyinosinic:polycytidylic acid stabilized with poly-L-lysine) was delivered to two separate groups of pregnant rhesus monkeys to induce MIA: 1) late first trimester MIA (n = 6), and 2) late second trimester MIA (n = 7). Control animals (n = 11) received saline injections at the same first or second trimester time points or were untreated. Sickness behavior, temperature, and cytokine profiles of the pregnant monkeys confirmed a strong inflammatory response to MIA. RESULTS:Behavioral development of the offspring was studied for 24 months. Following weaning at 6 months of age, MIA offspring exhibited abnormal responses to separation from their mothers. As the animals matured, MIA offspring displayed increased repetitive behaviors and decreased affiliative vocalizations. When evaluated with unfamiliar conspecifics, first trimester MIA offspring deviated from species-typical macaque social behavior by inappropriately approaching and remaining in immediate proximity of an unfamiliar animal. CONCLUSIONS:In this rhesus monkey model, MIA yields offspring with abnormal repetitive behaviors, communication, and social interactions. These results extended the findings in rodent MIA models to more human-like behaviors resembling those in both autism and schizophrenia.

| S-EPMC6782053 | biostudies-literature

Epigenetic abnormality due to maternal Zika virus infection [snRNA-seq]

Project description:We report the application of single nucleus RNA-seq and Enzymatic Methyl-seq in the prefrontal cortex from the mice treated with maternal zika virus infection

2021-06-30 | GSE164782 | GEO

Epigenetic abnormality due to maternal Zika virus infection [Methyl-seq]

Project description:We report the application of single nucleus RNA-seq and Enzymatic Methyl-seq in the prefrontal cortex from the mice treated with maternal zika virus infection

2021-06-30 | GSE164749 | GEO

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