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Innate immune sensing of influenza virus through IFI16 promote pyroptosis.

ABSTRACT: We report that IFI16, which was previously identified as a cytosolic DNA sensor, is essential for the activation of programmed cell death pathways in IAV infected cells. We have identified IFI16 as an innate immune sensor of the influenza A virus. We find that IFI16 recognizes viral genomic RNA upon infection. The activation of IFI16, in turn, triggers the production of type I, III interferons, and also other pro-inflammatory cytokines via the STING-TBK1 and Pro-caspase-1 signalling axis, thereby promoting cell death (apoptosis and pyroptosis in IAV infected cells).

ORGANISM(S): Homo sapiens

PROVIDER: GSE163705 | GEO | 2021/12/31

REPOSITORIES: GEO

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ZBP1 is a cytosolic RNA virus sensor driving activation of the NLRP3 inflammasome, pyroptosis, necroptosis and apoptosis

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Innate immune sensing of influenza virus through IFI16 promote pyroptosis.

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