A novel microglial transcription profile is driven by sex and APOE4 interactions in both mouse and human models of Alzheimer’s disease
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ABSTRACT: Using a transgenic mouse model of AD that expresses human APOE, we identify a unique transcriptional profile associated with APOE4 expression. We also show a sex and APOE interaction, such that both female sex and APOE4 drive expression of this gene profile. We then confirm these findings in human cells, using microglia derived from induced pluripotent stem cells.
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE163857 | GEO | 2021/09/21
REPOSITORIES: GEO
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