Transcriptomics

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A mechanism of cooling hot tumors: lactate attenuates inflammation in dendritic cells [BMDCs]


ABSTRACT: Lactic acid (LA) accumulation in the tumour environment occurs as a result of the accelerated glucose metabolism in tumour cells, the so-called Warburg effect. Because TLR4 agonists are one of the damage-associated molecular patterns, which are important stimulators of dendritic cells in the tumour microenvironment, we assessed the effects of LA on the response to LPS, the TLR4 ligand.

ORGANISM(S): Mus musculus

PROVIDER: GSE163975 | GEO | 2021/08/23

REPOSITORIES: GEO

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