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Regulated sulfur sequestration promotes multicellularity during nutrient limitation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Dictyostelium discoideum

PROVIDER: GSE164011 | GEO | 2021/02/24

REPOSITORIES: GEO

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Sulfur sequestration promotes multicellularity during nutrient limitation.

Project description:The behaviour of Dictyostelium discoideum depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species-generated as a consequence of nutrient limitation-lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron-sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes.

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

Project description:Dictyostelium discoideum behavior depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This unique biology makes D. discoideum an ideal model for investigating how fundamental metabolic pathways command cell differentiation and function. We show here that reactive oxygen species (ROS), generated as a consequence of nutrient limitation, lead to the sequestration of the amino acid cysteine in the antioxidant glutathione, limiting the use of its sulfur atom for processes such as protein translation and FeS cluster-containing enzyme activity that contribute to mitochondrial metabolism and cellular proliferation. Such regulated sulfur sequestration maintains D. discoideum in a non-proliferating state that paves the way for multicellular development. This new mechanism of ROS signaling highlights oxygen and sulfur as simple, early evolutionary signaling molecules dictating cell fate, with implications for responses to nutrient fluctuations in higher eukaryotes.

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

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Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

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An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

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