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Regulated sulfur sequestration promotes multicellularity during nutrient limitation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Dictyostelium discoideum

PROVIDER: GSE164011 | GEO | 2021/02/24

REPOSITORIES: GEO

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Sulfur sequestration promotes multicellularity during nutrient limitation.

Project description:The behaviour of Dictyostelium discoideum depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This biology makes D. discoideum an ideal model for investigating how fundamental metabolism commands cell differentiation and function. Here we show that reactive oxygen species-generated as a consequence of nutrient limitation-lead to the sequestration of cysteine in the antioxidant glutathione. This sequestration limits the use of the sulfur atom of cysteine in processes that contribute to mitochondrial metabolism and cellular proliferation, such as protein translation and the activity of enzymes that contain an iron-sulfur cluster. The regulated sequestration of sulfur maintains D. discoideum in a nonproliferating state that paves the way for multicellular development. This mechanism of signalling through reactive oxygen species highlights oxygen and sulfur as simple signalling molecules that dictate cell fate in an early eukaryote, with implications for responses to nutrient fluctuations in multicellular eukaryotes.

| S-EPMC7969356 | biostudies-literature

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

Project description:Dictyostelium discoideum behavior depends on nutrients1. When sufficient food is present these amoebae exist in a unicellular state, but upon starvation they aggregate into a multicellular organism2,3. This unique biology makes D. discoideum an ideal model for investigating how fundamental metabolic pathways command cell differentiation and function. We show here that reactive oxygen species (ROS), generated as a consequence of nutrient limitation, lead to the sequestration of the amino acid cysteine in the antioxidant glutathione, limiting the use of its sulfur atom for processes such as protein translation and FeS cluster-containing enzyme activity that contribute to mitochondrial metabolism and cellular proliferation. Such regulated sulfur sequestration maintains D. discoideum in a non-proliferating state that paves the way for multicellular development. This new mechanism of ROS signaling highlights oxygen and sulfur as simple, early evolutionary signaling molecules dictating cell fate, with implications for responses to nutrient fluctuations in higher eukaryotes.

2021-02-24 | GSE164010 | GEO

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

2021-02-24 | GSE164009 | GEO

Regulated sulfur sequestration promotes multicellularity during nutrient limitation

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation

| PRJNA688505 | ENA

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation (scRNA-Seq)

| PRJNA688507 | ENA

Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

Project description:Regulated sulfur sequestration promotes multicellularity during nutrient limitation (RNA-Seq)

| PRJNA688508 | ENA

An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.

Project description:Acinetobacter baumannii is an important nosocomial pathogen capable of causing wound infections, pneumonia, and bacteremia. During infection, A. baumannii must acquire Zn to survive and colonize the host. Vertebrates have evolved mechanisms to sequester Zn from invading pathogens by a process termed nutritional immunity. One of the most upregulated genes during Zn starvation encodes a putative cell wall-modifying enzyme which we named ZrlA. We found that inactivation of zrlA diminished growth of A. baumannii during Zn starvation. Additionally, this mutant strain displays increased cell envelope permeability, decreased membrane barrier function, and aberrant peptidoglycan muropeptide abundances. This altered envelope increases antibiotic efficacy both in vitro and in an animal model of A. baumannii pneumonia. These results establish ZrlA as a crucial link between nutrient metal uptake and cell envelope homeostasis during A. baumannii pathogenesis, which could be targeted for therapeutic development.

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Cellulose-induced and Nutrient limitation-induced regulation of Phanaerochaete chrysosporium genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-03-30 | GSE14736 | GEO

Genome-wide transcriptional profiling of the purple sulfur bacterium Allochromatium vinosum DSM 180T during growth on different reduced sulfur compounds

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-07-29 | E-GEOD-44042 | biostudies-arrayexpress

Consistent Plant and Microbe Nutrient Limitation Patterns During Natural Vegetation Restoration.

Project description:Vegetation restoration is assumed to enhance carbon (C) sequestration in terrestrial ecosystems, where plant producers and microbial decomposers play key roles in soil C cycling. However, it is not clear how the nutrient limitation patterns of plants and soil microbes might change during vegetation restoration. We investigated the nutrient limitations of the plant and microbial communities along a natural vegetation restoration chronosequence (1, 8, 16, 31, and 50 years) following farmland abandonment in Qinling Mountains, China, and assessed their relationships with soil factors. The result showed that following natural vegetation restoration, the nitrogen (N) limitation of plant and microbial communities was alleviated significantly, and thereafter, it began to shift to phosphorus (P) limitation at a later stage. Plants showed P limitation 50 years after restoration, while microbial P limitation appeared 31 years later. The changes in plant nutrient limitation were consistent with those in microbial nutrient limitation, but soil microbes were limited by P earlier than plants. Random forest model and partial least squares path modeling revealed that soil nutrient stoichiometry, especially soil C:N ratio, explained more variations in plant and microbial nutrient limitation. Our study demonstrates that the imbalanced soil C:N ratio may determine the soil microbial metabolic limitation and further mediate the variation in plant nutrient limitation during natural vegetation restoration, which provides important insights into the link between metabolic limitation for microbes and nutrient limitation for plants during vegetation restoration to improve our understanding of soil C turnover in temperate forest ecosystems.

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