Nucleome Dynamics during Retinal Development [scRNA-seq/scATAC-seq_Mm]
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ABSTRACT: Single cell RNA-sequencing shows cell type specific expression of genes in the retina. Single cell ATAC-sequencing of the wild type retina revealed that chromatin in the Vsx2 CRC SE, a stage- and cell type-specific core regulatory circuit super-enhancer (CRC-SE) upstream of the Vsx2 gene, was only open in bipolar cells. Deletion of the Vsx2 CRC-SE in mice led to the loss of bipolar neurons in the retina, which was confirmed by scRNA-sequencing of Vsx2SEKO mice.
ORGANISM(S): Mus musculus
PROVIDER: GSE164044 | GEO | 2020/12/31
REPOSITORIES: GEO
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