Expression data from human primary fibroblasts treated with Trypanosoma cruzi-conditioned medium

ABSTRACT: The intracellular pathogen Trypanosoma cruzi secretes an activity that blocks TGF-β-dependent induction of connective tissue growth factor (CTGF/CCN2). Here, we address the mechanistic basis for T. cruzi-mediated interference of CTGF/CCN2 expression by examining host cell signaling pathways and the global inhibitory effect on TGF-β-dependent gene expression. We show that the expression of a discrete subset of TGF-β-inducible genes involved in cell proliferation, wound repair, and immune regulation are blocked by the soluble T. cruzi activity, demonstrating that this parasite-derived activity has broad, but specific effects on fibroblast gene regulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE16416 | GEO | 2011/09/09

SECONDARY ACCESSION(S): PRJNA116357

REPOSITORIES: GEO