Transcriptomics

Dataset Information

0

Bacterial Fitness Landscapes Stratify Based on Proteome Allocation Associated with Discrete Aero-types


ABSTRACT: The fitness landscape is a concept commonly used to describe evolution towards optimal phenotypes. It can be reduced to mechanistic detail using genome-scale models (GEMs) from systems biology. We use recently developed GEMs of Metabolism and protein Expression (ME-models) to study the distribution of Escherichia coli phenotypes on the rate-yield plane. We found that the measured phenotypes distribute non-uniformly to form a highly stratified fitness landscape. Systems analysis of ME-model simulations suggest that this stratification results from discrete ATP generation strategies. Accordingly, we define "aero-types", a phenotypic trait that characterizes how a balanced proteome can achieve a given growth rate by modulating 1) the relative utilization of oxidative phosphorylation, glycolysis, and fermentation pathways; and 2) the differential employment of electron-transport-chain enzymes. This global, quantitative, and mechanistic systems biology interpretation of fitness landscape formed upon proteome allocation offers a fundamental understanding of bacterial physiology and evolution dynamics.

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

PROVIDER: GSE164236 | GEO | 2021/01/05

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2020-11-17 | GSE140478 | GEO
2018-08-01 | GSE72020 | GEO
| PRJNA689602 | ENA
2022-02-22 | GSE165615 | GEO
| PRJNA927307 | ENA
2018-09-15 | GSE115725 | GEO
2015-04-12 | E-GEOD-67769 | biostudies-arrayexpress
2015-04-07 | E-GEOD-63887 | biostudies-arrayexpress
2019-04-18 | GSE128812 | GEO
2021-12-30 | E-MTAB-10019 | biostudies-arrayexpress