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Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

ABSTRACT: We report trancriptional changes between wildtype C57BL/6J and in mice harboring a spontaneous missense mutation in Pdss2 (V117M, Pdss2 kd/kd).

ORGANISM(S): Mus musculus

PROVIDER: GSE164273 | GEO | 2021/02/01

REPOSITORIES: GEO

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Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

Project description:Single nucleus RNA sequencing of kidney from five-month-old Pdss2 kd/kd mice compared to age-matched controls

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Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

Project description:To discern whether the same transcriptional signature of mitochondrial dysfunction previously reported in B6.Alb/cre,Pdss2loxP/loxP liver-conditional knockout mice (Peng, Falk et al. PLoS Genetics, 2008 [PMID 18437205]) was present regardless of Pdss2 mutation type, as well as to assess whether pharmacologic therapies modulate expression of particular pathways, genome-wide transcriptional profiling was performed in liver from B6.Pdss2(kd/kd) missense mutant mice on standard chow or supplemented long-term with either probucol or CoQ10. For analysis of lifelong probucol and CoQ10 supplementation effects in B6.Pdss2(kd/kd) missense mutant mice, total RNA was isolated from the livers of B6 mice and from Pdss2(kd/kd) missense mutant mice fed a normal diet, or a diet supplemented with Probucol or CoQ10. Total RNA was individually hybridized to 20 total Illumina Mouse WG-6 v2.0 arrays, which included 5 biological replicates from each of the 4 groupings: untreated B6.Pdss2(kd/kd) missense mutant mice, probucol-treated B6.Pdss2(kd/kd) mice, CoQ10-treated B6.Pdss2(kd/kd) mice, and untreated B6 wild-type mice. Total RNA

2011-06-07 | E-GEOD-27954 | biostudies-arrayexpress

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

2011-06-07 | GSE27954 | GEO

RNA sequencing of mouse podocytes with and without knockdown of Pdss2

Project description:We report trancriptional changes between wildtype mouse immortalized podocytes and compared to podocytes with shRNA-knockdown of Pdss2.

2021-02-01 | GSE164272 | GEO

Five-month-old infants' identification of the sources of vocalizations.

Project description:Humans speak, monkeys grunt, and ducks quack. How do we come to know which vocalizations animals produce? Here we explore this question by asking whether young infants expect humans, but not other animals, to produce speech, and further, whether infants have similarly restricted expectations about the sources of vocalizations produced by other species. Five-month-old infants matched speech, but not human nonspeech vocalizations, specifically to humans, looking longer at static human faces when human speech was played than when either rhesus monkey or duck calls were played. They also matched monkey calls to monkey faces, looking longer at static rhesus monkey faces when rhesus monkey calls were played than when either human speech or duck calls were played. However, infants failed to match duck vocalizations to duck faces, even though infants likely have more experience with ducks than monkeys. Results show that by 5 months of age, human infants generate expectations about the sources of some vocalizations, mapping human faces to speech and rhesus faces to rhesus calls. Infants' matching capacity does not appear to be based on a simple associative mechanism or restricted to their specific experiences. We discuss these findings in terms of how infants may achieve such competence, as well as its specificity and relevance to acquiring language.

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PIE2-KD

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METTL3 KD in HepG2 cells

Project description:To gain insight into possible processes that require m6A for their function, METTL3 was knocked down (KD) in HepG2 cells by siRNA transfections Differential expression analysis of METTL3 KD versus mock-transfected HepG2 cells, in 2 biological replicates

2012-04-25 | E-GEOD-37001 | biostudies-arrayexpress

Automatic facial mimicry in response to dynamic emotional stimuli in five-month-old infants.

Project description:Human adults automatically mimic others' emotional expressions, which is believed to contribute to sharing emotions with others. Although this behaviour appears fundamental to social reciprocity, little is known about its developmental process. Therefore, we examined whether infants show automatic facial mimicry in response to others' emotional expressions. Facial electromyographic activity over the corrugator supercilii (brow) and zygomaticus major (cheek) of four- to five-month-old infants was measured while they viewed dynamic clips presenting audiovisual, visual and auditory emotions. The audiovisual bimodal emotion stimuli were a display of a laughing/crying facial expression with an emotionally congruent vocalization, whereas the visual/auditory unimodal emotion stimuli displayed those emotional faces/vocalizations paired with a neutral vocalization/face, respectively. Increased activation of the corrugator supercilii muscle in response to audiovisual cries and the zygomaticus major in response to audiovisual laughter were observed between 500 and 1000 ms after stimulus onset, which clearly suggests rapid facial mimicry. By contrast, both visual and auditory unimodal emotion stimuli did not activate the infants' corresponding muscles. These results revealed that automatic facial mimicry is present as early as five months of age, when multimodal emotional information is present.

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Gene expression analysis of kidney primary tubular epithelial cells (PTECs), SETD2-KD PTECs, PBRM1-KD PTECs and ccRCC derived cell lines

Project description:Transcriptional profiling of human WT-PTECs, SETD2-KD PTECs, PBRM1-KD PTECs, and 10 different ccRCC derived cell lines. ccRCC derived cell lines showed distict expression signatures as compared to PTECs, some of them also present in SETD2-KD PTECs, and/or PBRM1-KD PTECs.

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