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Frontal Cortex whole transcriptome sequencing in COVID-19 elderly patients

ABSTRACT: SARS-Cov-2 infection is frequently associated with Nervous System (NS) manifestations. However, it is not clear how SARS-CoV-2 can cause neurological dysfunctions and which molecular processes affects. In this work, we examined the frontal cortex tissue of patients who died of COVID-19 for the presence of SARS-CoV-2, comparing qRT-PCR with ddPCR. We also investigated the transcriptomic profile of frontal cortex from COVID-19 patients and matched controls by RNA-seq analysis to characterize the transcriptional signature.

ORGANISM(S): Homo sapiens

PROVIDER: GSE164332 | GEO | 2021/03/09

REPOSITORIES: GEO

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