Spatially resolved single-cell RNA-sequencing reveals expression heterogeneity in tumor microenvironment
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ABSTRACT: To better understand how individual cells function within an anatomical space, we developed XYZeq, a novel scRNA-seq workflow that uses combinatorial indexing in microwells to encode spatial metadata into scRNA-seq libraries. We used XYZeq to profile heterotopic mouse liver and spleen tumor models to capture transcriptomes from tens of thousands of cells across a total of eight tissue slices.
ORGANISM(S): Mus musculus Homo sapiens
PROVIDER: GSE164430 | GEO | 2021/01/08
REPOSITORIES: GEO
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