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ChIP-seq for TCF7L2/TCF4 in E16.5 intestinal epithelial cells

ABSTRACT: As part of our comprehensive characterization of intestinal development, we performed ChIP-seq for TCF7L2/TCF4 in mouse E16.5 intestinal epithelial cells. We identified more than 6000 regions bound by TCF7L2/TCF4 including a binding site in an enhancer driving Shh expression. Combined with transcriptional and functional analyses, our data reveal a novel cross-talk between WNT and Hedgehog signaling pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE164442 | GEO | 2021/12/11

REPOSITORIES: GEO

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ChIP-seq for TCF7L2/TCF4 in E16.5 intestinal epithelial cells

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Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

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