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Identification of NEDD9 regulated genes in VCaP prostate cancer cells

ABSTRACT: NEDD9 gene (Neural precursor Expressed, Developmentally Down-regulated 9) encodes a member of the Cas family of signaling transduction molecules, which is a non-catalytic focal adhesion protein phosphorylated by FAK and Src and functions as a signaling hub to regulate downstream signaling, such as the AKT pathway. In cancers, NEDD9 regulates cell migration, epithelial-mesenchymal transition (EMT), invasion, and metastasis. Gene amplification of NEDD9 is commonly found in the advanced metastatic castration-resistant PCa (~3%) and neuroendocrine PCa (~15%), suggesting NEDD9 may play an important role in PCa progression. In order to characterize the global functions of NEDD9 in PCa cells, we performed RNA-seq analyses in VCaP cells (containing NEDD9 gene amplification) stably infected with shRNA against NEDD9 or non-targeting control (NTC).

ORGANISM(S): Homo sapiens

PROVIDER: GSE164531 | GEO | 2021/01/11

REPOSITORIES: GEO

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Clorgyline treatment of VCaP cells

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Identification of NEDD9 regulated genes in VCaP prostate cancer cells

Project description:Identification of NEDD9 regulated genes in VCaP prostate cancer cells

| PRJNA691065 | ENA

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