Transcriptomics

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Expression data from side population subfraction hematopoietic stem cells


ABSTRACT: The traditional view of hematopoiesis has been that all the cells of the peripheral blood are the progeny of a unitary homogeneous pool of hematopoietic stem cells (HSCs). Recent evidence suggests that the hematopoietic system is actually maintained by a consortium of HSC subtypes with distinct functional characteristics. We show here that myeloid-biased HSCs (My-HSCs) and lymphoid-biased (Ly-HSCs) can be purified according to their capacity for Hoechst dye efflux in combination with canonical HSC markers. We used microarray expression profiling to determine the transcriptional profiles of myeloid-biased lower-SP HSCs and lymphoid-biased upper-SP HSCs

ORGANISM(S): Mus musculus

PROVIDER: GSE16475 | GEO | 2010/03/01

SECONDARY ACCESSION(S): PRJNA116315

REPOSITORIES: GEO

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