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Annotation- and Batch Effect Correction in TCGA IsomiR Expression Data [Third-party re-analysis]

ABSTRACT: The Cancer Genome Atlas (TCGA) Isoform Expression Quantification Data is the largest ressource of isomiR level sequenced cancer data publicly available. Since the datasets were built up over years and through different contributing institutions, it is not free of batch effects. We evaluated different batch correction approaches to remove batch effects in the data, details of the best performing algorithm and batch variables are included in the supplementary file. Additionally, annotation of the chromosomal end position of each isomiR feature was corrected by the offset of 1 to account for exclusive annotation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE164767 | GEO | 2021/02/17

REPOSITORIES: GEO

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