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Bach2 attenuates IL-2R signalling to control Treg homeostasis and Tfr development

ABSTRACT: Differentiation and homeostasis of Foxp3 + regulatory T cells (Tregs) are tightly controlled by the interleukin-2 receptor (IL-2R) signaling, yet the mechanisms governing these processes are incompletely understood. Here we report that transcription factor Bach2 attenuates IL-2R signaling to coordinate Treg differentiation and homeostasis by directly repressed CD25 (IL-2Rα). Thus, Bach2 balances IL-2R signaling to orchestrate development and homeostasis of various Treg subsets.

ORGANISM(S): Mus musculus

PROVIDER: GSE164937 | GEO | 2021/05/11

REPOSITORIES: GEO

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Bach2 attenuates IL-2R signalling to control Treg homeostasis and Tfr development

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