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Transcriptome profile of Escherichia coli K12 MG1655 cells lacking selected genes

ABSTRACT: The aim of the study was to compare the transcriptome of E. coli K12 MG1655 cells lacking genes known to induce the Rtc RNA repair system, such as gor, mazF and srmB, to wild-type cells. In all cases, less than 1% of the genes were found to be differentially expressed.

ORGANISM(S): Escherichia coli str. K-12 substr. MG1655

PROVIDER: GSE165008 | GEO | 2022/11/02

REPOSITORIES: GEO

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Transcriptome profile of Escherichia coli K12 MG1655 Hpx- cells

Project description:The aim of the study was to compare the transcriptome of E. coli K12 MG1655 cells lacking hydroperoxidase (Hpx-) and therefore unable to detoxify hydrogen peroxide, to wild-type cells; both when the Rtc RNA repair system is active and when it is inhibited; at 8 and 24 hpi. A very large number of genes (up to 1/3) were found to be differentially expressed in Hpx- as compared to wild-type. Inhibition of the Rtc system had dramatic effects on Hpx- but not on wild-type.

2022-11-02 | GSE165009 | GEO