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Transcriptome sequencing revealed a set of differentially expressed related genes between systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosis (PF)

ABSTRACT: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by abnormal immune responses that include aberrant activation of autoreactive T and B lymphocytes, with subsequent production of pathogenic autoantibodies and formation of immune complexes leading to organ injury. Pulmonary involvement in SLE is common and protean with different clinical manifestations ranging from acute pneumonitis, pulmonary hemorrhage to pulmonary fibrosis (PF). The health status of SLE patients with pulmonary disease is relatively poor, and the mortality rate is high, but research on SLE pulmonary domain is still lacking. In order to further explore the difference between SLE with PF and SLE without PF, we perform transcriptome sequencing analysis. The PBMCs from 3 SLE patients with PF and 3 SLE without PF were drawn, and RNA-seq was performed with subsequent bioinformatics analysis. Compared with the SLE patients without PF, the genes that changed in all three SLE patients with PF included 647 significantly up-regulated and 1364 significantly down-regulated differentially expressed genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165159 | GEO | 2024/01/20

REPOSITORIES: GEO

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Transcriptome sequencing revealed a set of differentially expressed related genes between systemic lupus erythematosus (SLE) patients with and without pulmonary fibrosis (PF)

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