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Expression data from FACS sorted cell populations of immortalized stromovascular fraction mouse cells derived from inguinal white adipose tissue, showing either high or low binding to FcsFNDC4

ABSTRACT: Soluble FNDC4 (sFNDC4) is a novel hepatokine which promotes glucose tolerance in mice and positively associates with increased glucose tolerance in humans. To identify potential receptors for sFNDC4 we screened a population of immortalized stromovascular mouse cells derived from inguinal white fat for cells, which showed high (high binding cells-HBC) or low binding (low binding cells-LBC) to recombinant FcsFNDC4. We utilised microarray to identify differentially expressed genes between HBC and LBC. After comparing the global gene expression between HBC and LBC we were able to identify several differentially expressed genes encoding for cellular receptors. Experimental validations of these results and further experimental sutdies supported that GPR116 is the receptor for sFNDC4.

ORGANISM(S): Mus musculus

PROVIDER: GSE165329 | GEO | 2021/02/01

REPOSITORIES: GEO

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