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Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE165348 | GEO | 2021/05/14

REPOSITORIES: GEO

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Stable Epigenetic Programming of Effector and Central Memory CD4 T Cells Occurs Within 7 Days of Antigen Exposure <i>In Vivo</i>.

Project description:T cell immunological memory is established within days of an infection, but little is known about the in vivo changes in gene regulatory networks accounting for their ability to respond more efficiently to secondary infections. To decipher the timing and nature of immunological memory we performed genome-wide analyses of epigenetic and transcriptional changes in a mouse model generating antigen-specific T cells. Epigenetic reprogramming for Th differentiation and memory T cell formation was already established by the peak of the T cell response after 7 days. The Th memory T cell program was associated with a gain of open chromatin regions, enriched for RUNX, ETS and T-bet motifs, which remained stable for 56 days. The epigenetic programs for both effector memory, associated with T-bet, and central memory, associated with TCF-1, were established in parallel. Memory T cell-specific regulatory elements were associated with greatly enhanced inducible Th1-biased responses during secondary exposures to antigen. Furthermore, memory T cells responded in vivo to re-exposure to antigen by rapidly reprograming the entire ETS factor gene regulatory network, by suppressing Ets1 and activating Etv6 expression. These data show that gene regulatory networks are epigenetically reprogrammed towards memory during infection, and undergo substantial changes upon re-stimulation.

| S-EPMC8181421 | biostudies-literature

Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (RNA-seq)

Project description:T cell immunological memory is established within days of an infection but little is known about the in vivo changes in gene regulatory networks which account for the ability of memory T cells to respond more efficiently to secondary infections. To decipher the timing and nature of immunological memory we performed genome-wide analyses of epigenetic and transcriptional changes in a mouse model generating antigen-specific T cells.

2021-05-14 | GSE165347 | GEO

Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (ATAC-seq)

2021-05-14 | GSE165346 | GEO

Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo

Project description:Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo

| PRJNA694139 | ENA

Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (RNA-seq)

Project description:Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (RNA-seq)

| PRJNA694140 | ENA

Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (ATAC-seq)

Project description:Stable epigenetic programming of effector and central memory CD4 T cells occurs within 7 days of antigen exposure in vivo (ATAC-seq)

| PRJNA694141 | ENA

Transcription profiling of human CD8 naive (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells

Project description:Memory T cells are heterogeneous in terms of their phenotype and functional properties. We investigated the molecular profiles of human CD8 naïve (TN), central memory (TCM), effector memory (TEM), and effector memory RA (TEMRA) T cells using gene expression microarrays and phospho-protein-specific intracellular flow cytometry. We demonstrate that TCM have a gene expression and cytokine signaling signature that lies between that of TN and TEM or TEMRA cells, whereas TEM and TEMRA are closely related. Our data define the molecular basis for the different functional properties of central and effector memory subsets. We show that TEM and TEMRA cells strongly express genes with known importance in CD8 T cell effector function. In contrast, TCM are characterized by high basal and cytokine-induced STAT5 phosphorylation, reflecting their capacity for self-renewal. Altogether, our results distinguish TCM and TEM/TEMRA at the molecular level and are consistent with the concept that TCM represent memory stem cells.

2005-01-01 | E-TABM-40 | biostudies-arrayexpress

Transcription profiling of in vitro generated CD8+ central memory (CM) and effector/effector memory (E/EM) T cells.

Project description:Expression profiles of in vitro generated CD8+ central memory (CM) and effector/effector memory (E/EM) T cells on Affymetrix GeneChip Murine Genome U74 Version 2 Set MG-U74A, MG-U74B, and MG-U74C. T cells were generated from female P14 T cell receptor transgenic mice on the C57Bl/6 genetic background.

2007-12-15 | E-GEOD-561 | biostudies-arrayexpress

Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-11-26 | GSE228887 | GEO

Antigen-specific decidual CD8+ T cells include distinct effector memory and tissue-resident memory cells.

Project description:Maternal decidual CD8+ T cells must integrate the antithetical demands of providing immunity to infection while maintaining immune tolerance for fetal and placental antigens. Human decidual CD8+ T cells were shown to be highly differentiated memory T cells with mixed signatures of dysfunction, activation, and effector function. However, no information is present on how specificity for microbial or fetal antigens relates to their function or dysfunction. In addition, a key question, whether decidual CD8+ T cells include unique tissue-resident memory T cells (Trm) or also effector memory T cell (Tem) types shared with peripheral blood populations, is unknown. Here, high-dimensional flow cytometry of decidual and blood CD8+ T cells identified 2 Tem populations shared in blood and decidua and 9 functionally distinct Trm clusters uniquely found in decidua. Interestingly, fetus- and virus-specific decidual CD8+ Trm cells had similar features of inhibition and cytotoxicity, with no significant differences in their expression of activation, inhibitory, and cytotoxic molecules, suggesting that not all fetus-specific CD8+ T cell responses are suppressed at the maternal-fetal interface. Understanding how decidual CD8+ T cell specificity relates to their function and tissue residency is crucial in advancing understanding of their contribution to placental inflammation and control of congenital infections.

| S-EPMC10544202 | biostudies-literature

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