Transcriptomics

Dataset Information

0

Serine Metabolism Antagonizes Antiviral Innate Immunity Through Preventing ATP6V0d2-mediated YAP Lysosomal Degradation


ABSTRACT: Here, we demonstrate that virus-infected macrophages display decreased expression of serine synthesis pathway (SSP) enzymes. Suppressing the SSP key enzyme phosphoglycerate dehydrogenase (PHGDH) by genetic approaches enhanced IFN-b-mediated antiviral innate immunity in vitro and in vivo. To further explore its mechanism, we used high-throughput sequencing technology (RNA-seq) to assess gene expression in PHGDH-deficiency BMDMs and RAW264.7 macrophages.

ORGANISM(S): Mus musculus

PROVIDER: GSE165684 | GEO | 2021/01/29

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-02-19 | GSE196840 | GEO
2022-07-11 | GSE207435 | GEO
2024-01-27 | GSE236357 | GEO
2024-06-03 | GSE246566 | GEO
2024-08-15 | GSE263499 | GEO
2018-08-14 | PXD007790 | Pride
2021-11-04 | GSE144506 | GEO
2023-07-20 | PXD017809 | Pride
2022-07-29 | PXD035287 |
2008-06-17 | E-GEOD-8555 | biostudies-arrayexpress