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Microglial activation protects from vascular degeneration in a rat model of inflammatory retinal vasoregression.

ABSTRACT: Microglial activation represents a hallmark of inflammatory retinal diseases like diabetic retinopathy. Anti-inflammatory and especially microglia modulating approaches have been proposed as therapies for these diseases. In this study, clodronate-coated liposomes were intravitreally injected to investigate the effects of increased microglial activation on vasoregression in a model of retinal degeneration. Clodronate-coated liposomes, injected twice over a period of 5 weeks to study the effects of long term clodronate treatment on microglial activation, vasoregression (acellular capillary formation and pericyte loss) and to identify the pathways mediating the observed effects.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE165743 | GEO | 2021/01/29

REPOSITORIES: GEO

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