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High-frequency head impacts cause chronic synaptic adaptations and long-term cognitive impairment [Memantine study]

ABSTRACT: The goal of this study is to use bulk RNA-sequencing of to observe the effects of High Frequency Head Impacts contibuting to cognitive dysfunction in mice. Our results show HF-HI can alter brain function through synaptic adaptation. HF-HI mice develop chronic cognitive impairments in the absence of traditional brain trauma pathology, and transcriptomic profiling reveals that synapses are a primary target of this effect.

ORGANISM(S): Mus musculus

PROVIDER: GSE165759 | GEO | 2021/01/29

REPOSITORIES: GEO

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