Transcriptomics

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AMPKalpha1, AMPKalpha2 and AMPKalpha1/2 double knock-down RNA-Seq


ABSTRACT: In non-small cell lung cancer the role of AMPKα is controversial and its contribution to lung carcinogenesis is not well-defined. To shed light on the molecular mechanisms through which AMPKα could be involved in lung tumorigenesis, we analysed by RNA-sequencing the whole transcriptome upon AMPKα1, AMPKα2 or AMPKα1/α2 knockdown (KD). Furthermore, it remains largely unknown whether long non-coding RNAs (lncRNAs) are involved in the regulation of AMPKα-mediated pathways. Therefore, we examined the lncRNA expression profile and searched for lncRNAs differentially expressed in the same conditions (AMPKα1, AMPKα2 or AMPKα1/α2 KD versus control) in H1299 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165843 | GEO | 2021/05/26

REPOSITORIES: GEO

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