Transcriptomics

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Transcriptome-wide expression changes over time in cultured primary human monocytes due to DMOG treatment


ABSTRACT: RNA sequencing of primary human monocytes cultured with and without hypoxia-mimetic agent DMOG (Dimethyloxalylglycine). Monocytes isolated from PBMCs of 7 healthy donors were cultured with and without DMOG for 24hrs and harvested at 0, 2, 10 or 24hrs for RNA sequencing. DMOG suppresses HIF Prolyl hydroxylase (HIF-PH) activity by acting as a small molecule competitive inhibitor. HIF-PH inhibition leads to increase in endogenous HIF protein levels and mimics aspects of hypoxia. This RNA-seq study allows analysis of transciptome-wide expression pattern changes over time due to DMOG treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE165998 | GEO | 2022/04/13

REPOSITORIES: GEO

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