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Identification of enhancer-promoter contacts in squamous cancer cells [HiChIP]

ABSTRACT: Profiling promoter-enhancer interactions in squamous cancer cell lines

ORGANISM(S): Homo sapiens

PROVIDER: GSE166232 | GEO | 2021/10/19

REPOSITORIES: GEO

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Identification of enhancer-promoter contacts in squamous cancer cells [HiChIP]

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Project description:We found that in addition to promoters, multiple Nups bind enhancers and insulators in the Drosophila genome. We identified a functional role for Nup98 in mediating enhancer-promoter looping at ecdysone-inducible genes. These genes were found to be stably associated with nuclear pores before and after activation. Interestingly, although changing the levels of Nup98 disrupted induced enhancer-promoter contact, it did not affect transcriptional activation. Instead, loss of Nup98-mediated enhancer-promoter contact affected the primed response to subsequent transcriptional activation or transcriptional memory. In support of the enhancer-looping role, we found Nup98 to gain and retain physical interactions with several architectural proteins upon stimulation with ecdysone.

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