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Epigenetic and transcriptomic profiling of neural stem cells after midazolam exposure

ABSTRACT: Here we show that early-life exposure to midazolam (MDZ), a widely used drug in pediatric anesthesia, persistently alters chromatin accessibility and expression of quiescence-associated genes in neural stem cells (NSCs) in mouse hippocampus. The alterations led to a continuous restriction of NSC proliferation toward adulthood, resulting in reduction of neurogenesis associated with the impairment of hippocampal-dependent memory functions. Moreover, we found that voluntary exercise restored hippocampal neurogenesis accompanied by the normalization of MDZ-perturbed transcriptome and ameliorated declined cognitive ability in MDZ-exposed mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE166322 | GEO | 2021/08/29

REPOSITORIES: GEO

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