Genomics

Dataset Information

0

Profiling of the chromatin landscape of hematopoietic progenitor cells (HPC) transduced with transcription factors T-BET and EOMES [ATAC-seq HPC]


ABSTRACT: T-BET and EOMES are key transcription factors in the development of mature Natural Killer (NK) cells in mice. However, the role of these transcription factors during human NK cell development is less well understood. Therefore, we overexpressed T-BET or EOMES in human umbilical cord blood-derived HPC and cultured them in vitro in an NK cell differentiation model. To evaluate the effect of early overexpression of T-BET and EOMES in HPC, the chromatin landscape was uncovered using assay for transposase-accessible chromatin (ATAC) sequencing. In this way, the regulatory effect of T-BET and EOMES overexpression on the epigenome of HPC was evaluated.

ORGANISM(S): Homo sapiens

PROVIDER: GSE166435 | GEO | 2021/08/27

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2021-08-27 | GSE166437 | GEO
2021-08-27 | GSE166438 | GEO
2021-08-27 | GSE166436 | GEO
2021-05-10 | GSE168241 | GEO
2023-06-06 | GSE227878 | GEO
2023-06-06 | GSE227636 | GEO
| PRJNA700968 | ENA
2021-05-10 | GSE168240 | GEO
| PRJNA700965 | ENA
| PRJNA706661 | ENA