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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

ABSTRACT: We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

ORGANISM(S): Mus musculus

PROVIDER: GSE166481 | GEO | 2021/03/17

REPOSITORIES: GEO

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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

Project description:We report on the dynamic regulation of H3K27me3 demethylation during early T cell activation

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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

Project description:This SuperSeries is composed of the SubSeries listed below.

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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation

| PRJNA701035 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ChIP-Seq)

| PRJNA701036 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (ATAC-Seq)

| PRJNA701039 | ENA

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq timecourse)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq timecourse)

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KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

Project description:KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation (RNA-Seq K6B)

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The histone lysine demethylase JMJD3/KDM6B is recruited to p53 bound promoters and enhancer elements in a p53 dependent manner

Project description:The JmjC domain containing protein JMJD3/KDM6B catalyses H3K27me3 and H3K27me2 demethylation. JMJD3 appears to be highly regulated at the transcriptional level and is upregulated in response to diverse stimuli such as differentiation inducers and stress signals. Accordingly, JMJD3 has been linked to the regulation of different biological processes such as differentiation of embryonic stem cells, inflammatory responses in macrophages, and induction of cellular senescence via regulation of the INK4A-ARF locus. Here we show here that JMJD3 interacts with the tumour suppressor protein p53. We find that the interaction is dependent on the p53 tetramerization domain. Following DNA damage, JMJD3 is transcriptionally upregulated and by performing genome-wide mapping of JMJD3, we demonstrate that it binds genes involved in basic cellular processes, as well as genes regulating cell cycle, response to stress and apoptosis. Moreover, we find that JMJD3 binding sites show significant overlap with p53 bound promoters and enhancer elements. The binding of JMJD3 to p53 target sites is increased in response to DNA damage, and we demonstrate that the recruitment of JMJD3 to these sites is dependent on p53 expression. Therefore, we propose a model in which JMJD3 is recruited to p53 responsive elements via its interaction with p53 and speculate that JMJD3 could act as a fail-safe mechanism to remove low levels of H3K27me3 and H3K27me2 to allow for efficient acetylation of H3K27. Examination of JMJD3 and p53 genome-wide binding in untreated BJ cells or cells exposed to DNA damage (IR, 10 Gy)

2014-06-11 | E-GEOD-55912 | biostudies-arrayexpress

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