Transcriptomics

Dataset Information

0

Single Cell Profiling Identifies the Histone Demethylase, JMJD3, Modulates Macrophage Phenotype in Abdominal Aortic Aneurysm Formation


ABSTRACT: Abdominal aortic aneurysm (AAA) is a life-threatening disease characterized by an inflammatory macrophage phenotype that contributes to pathological vascular remodeling. Although the mechanisms regulating macrophage-mediated inflammation during AAA development remain undefined, accumulating evidence suggests that epigenetic alterations play a critical role. Here using single cell RNA-sequencing techniques, we identify that the histone demethylase JMJD3  is elevated in human AAA monocytes/macrophages, resulting in the upregulation of cellular activation and a proinflammatory immune response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE166676 | GEO | 2021/02/13

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2023-12-07 | GSE183464 | GEO
2015-06-30 | E-GEOD-57691 | biostudies-arrayexpress
2023-06-08 | GSE222440 | GEO
| PRJNA701583 | ENA
2019-10-14 | GSE129881 | GEO
2023-07-18 | GSE237067 | GEO
2024-01-01 | GSE242284 | GEO
2023-08-30 | GSE237230 | GEO
2018-12-27 | GSE119717 | GEO
2021-08-15 | GSE175683 | GEO