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Mycobacterium tuberculosis transcriptional response to Pyrazinoic acid

ABSTRACT: The ability of Mycobacterium tuberculosis (Mtb) to adopt heterogeneous physiological states, underlies it’s success in evading the immune system and tolerating antibiotic killing. Drug tolerant phenotypes are a major reason why the tuberculosis (TB) mortality rate is so high, with over 1.8 million deaths annually. To develop new TB therapeutics that better treat the infection (faster and more completely), a systems-level approach is needed to reveal the complexity of network-based adaptations of Mtb. Here, we report the transcriptional response of Mtb to the drug Pyrazinoic acid . We performed transcriptomic sequencing (RNA-seq) on Mtb bacilli at 4, 24, 72 h following exposure to the drug.

ORGANISM(S): Mycobacterium tuberculosis H37Rv

PROVIDER: GSE166677 | GEO | 2021/12/15

REPOSITORIES: GEO

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